Pharmaceutical formulations containing mitochondrially targeted antioxidants

A method of treatment of an inflammatory disorder selected from the group consisting of acute pyelonephritis, hepatitis, and pancreatitis, the method comprising treating a subject having the inflammatory disorder with one or more mitochondrially targeted antioxidant having the structure:

• wherein:
• A is an effector moiety having a following structure:
• and reduced forms thereof, wherein:
• m is an integer from 1 to 3;
• each Y is independently selected from the group consisting of:
• lower alkyl;
• lower alkoxy;
• or
• two adjacent Y groups, together with carbon atoms to which they are attached, form a following structure:
• and reduced forms thereof;
• wherein:
• R1 and R2 may be the same or different and are each independently lower alkyl or lower alkoxy;
• L is a linker group, comprising:
• a) a straight or branched hydrocarbon chain which can be optionally substituted by one or more substituents and optionally contains one or more double or triple bonds;
• or
• b) a natural isoprene chain;
• n is integer from 1 to 40, or from 2 to 15, or from 5 to 11;
• B is a targeting group comprising Sk+Z−, wherein:
• Sk is a lipophilic cation;
• and
• Z is a pharmacologically-acceptable anion;
• and solvates, salts, and stereoisomers thereof.