Rearranged TT virus molecules for use in diagnosis, prevention and treatment of cancer and autoimmunity

An expression vector comprising a rearranged torque teno virus (TTV) polynucleic acid comprising one of the nucleotide sequences of SEQ ID NOs:

• 228-231, wherein said nucleotide sequence is linked to a polynucleic acid encoding a polypeptide containing a signature motif of a mammalian protein being associated with cancer or an autoimmune disease, wherein the signature motif is at least 10 aa and has a degree of identity to a corresponding signature motif in a mammalian protein of at least 90% and said signature motif is selected from the group consisting of a protamine 1 signature motif having one of the sequences of SEQ ID NOs:17, 19, 22, and 241, a protamine 2 signature motif having one of the sequences of SEQ ID NOs:18, 20, 21, and 23, an opsin signature motif having one of the sequences of SEQ ID NOs:
• 1-16, and 36, a galanin signature motif having one of the SEQ ID NOs:26-28, a male specific protein signature motif having one of the SEQ ID NOs:53-54, a gastrin signature motif having one of the SEQ ID NOs:38-43, a collagen signature motif having one of the SEQ ID NOs:46-52, a collagenase metalloprotease signature motif having one of the SEQ ID NOs:44-45, a microbial collagenase metalloprotease (M9) signature motif having one of the SEQ ID NOs:55-60, a MIC1 microneme protein signature motif having one of the SEQ ID NOs:61-64:
• autoimmune regulator (AIRE) signature having one of the SEQ ID NOs:66-70, a gliadin signature motif having one of the SEQ ID NOs:72-77 and 155, a neuropeptide Y2 receptor signature motif having one of the SEQ ID NOs:79-81, an aerolysin signature motif having one of the SEQ ID NOs:83-87, an orexin signature motif having one of the SEQ ID NOs:89-95, a prion signature motif having one of the SEQ ID NOs:97-103, a neurotensin signature motif having one of the SEQ ID NOs:105-108, an orphan nuclear receptor (4A nuclear receptor) family signature motif having one of the SEQ ID NOs:110-117, a brain derived neurotrophic factor (BDN) signature motif having one of the SEQ ID NOs:118-119, a calcitonin signature motif having one of the SEQ ID NOs:121-128, a leukotrine B4 type 1 receptor signature motif having one of the SEQ ID NOs:129-135, a vasopressin signature motif having one of the SEQ ID NOs:136-147, a melanin concentrating hormone 2 receptor signature motif having one of the SEQ ID NOs:149-150, a prostanoid EP1 receptor signature motif having one of the SEQ ID NOs:152-154, a cyclin kinase signature motif having one of the SEQ ID NOs:158-169, a peroxisome proliferator-activated receptor signature motif having one of the SEQ ID NOs:171-178, a muscarinic M1 receptor signature motif having one of the SEQ ID NOs:180-184, a metabotropic gamma-aminobutyric acid type B2 receptor signature motif having one of the SEQ ID NOs:186-188, an argininge deiminase signature motif having one of the SEQ ID NOs:156 and 190-199, an opioid growth factor receptor repeat signature motif having the SEQ ID NO:201, an adhesion molecule CD36 signature motif having one of the SEQ ID NOs:203-209, a myelin proteolipid protein signature motif having the SEQ ID NO:211, and a chlamidiaom signature motif having the SEQ ID NO:213, wherein the rearranged TTV polynucleic acid is operably linked to prokaryotic, eukaryotic or viral transcription and translation control elements and comprising nucleic acid sequence providing expression of a desired open reading frame.