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US 9,573,951 B2Granted
Crystalline forms of a purine derivative
AssigneeCyclacel Limited
InventorsBenjamin Mark Skead, Christopher Peter Worrall, Jonathan Charles Christian Atherton, Julian Scott Northen, Philippe Fernandes
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Abstract
The present invention relates to new crystalline forms of a purine derivative which exhibits excellent anti-tumor activity. The invention also relates to a pharmaceutical composition containing said crystalline forms as an active ingredient, and use thereof in the prevention or treatment of disease. The invention further relates to a process for preparing the crystalline forms.
Claims5
A crystalline form of compound (I),
- wherein said compound is in the form of the free base and which is characterized by an x-ray powder diffraction pattern having two or more diffraction peaks at 2[theta] values selected from 7.53±0.2, 9.60±0.2, 10.22±0.2, 11.29±0.2, 11.66±0.2, 12.26±0.2, 12.62±0.2, 13.17±0.2, 14.06±0.2, 14.85±0.2, 15.15±0.2, 15.57±0.2, 16.99±0.2, 17.68±0.2, 18.30±0.2, 18.39±0.2, 18.63±0.2, 18.97±0.2, 19.32±0.2 and 20.20±0.2.
A process for preparing crystalline free base of compound (I),
- wherein said compound is in the form of the free base and which is characterized by an x-ray powder diffraction pattern having two or more diffraction peaks at 2[theta] values selected from 7.53±0.2, 9.60±0.2, 10.22±0.2, 11.29±0.2, 11.66±0.2, 12.26±0.2, 12.62±0.2, 13.17±0.2, 14.06±0.2, 14.85±0.2, 15.15±0.2, 15.57±0.2, 16.99±0.2, 17.68±0.2, 18.30±0.2, 18.39±0.2, 18.63±0.2, 18.97±0.2, 19.32±0.2 and 20.20±0.2,
- wherein said method comprises the steps of crystallising compound (I) in free base form from methyl t-butyl ether (MTBE).
Dependencies are inferred from the claim text.