US 9,519,291 B2 · Coordination of solvent delivery with pre-injection operations in a liquid chromatograph

Abstract

A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection.

Claims15

Dependent claims

A method for introducing a sample to a solvent stream, comprising:

calculating a first amount of time for completing pre-injection operations of an autosampler and a second amount of time for delivering the solvent stream to the autosampler;
comparing the first amount of time and the second amount of time to identify which amount of time is greater than the other amount of time and to quantify a time difference between the amounts of time;
starting pre-injection operations by the autosampler to make the sample ready for injection into the solvent stream;
and
starting delivery of the solvent stream to the autosampler, wherein the starting of the pre-injection operations and the starting of the delivery of the solvent stream occur at times that differ by approximately the time difference.

2 more elements

Dependencies are inferred from the claim text.

Coordination of solvent delivery with pre-injection operations in a liquid chromatograph

Life of this patent

Coordination of solvent delivery with pre-injection operations in a liquid chromatograph

Life of this patent

Abstract

Claims15