US 9,519,002 B2 · Device, system, and method for selecting a target analyte

Abstract

This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a specimen. The magnetic gradient may be introduced by a magnet, such as a permanent magnet or an electromagnet, and the pressure gradient may be introduced by a pump which moves within a fluid-primed cannula to create the pressure gradient, thereby drawing the target analyte into the cannula. The picker may also expel the target analyte onto or into a substrate, such as a well plate, after the target analyte has been drawn into the picker by reversing the pressure gradient or removing the magnetic gradient.

Claims6

Dependent claims

A system comprising:

a picker including
a pump block including a first end and a second end including a seal;
a piston at least partially housed within the pump block and partially extending through the seal, the pump block to allow translation of the piston relative to the pump block;
a cannula including an adapter end and a tube end, wherein the adapter end connects to the pump block with the tube end extended away from the pump block;
a driver;
a coupling to mate the driver to the piston;
an actuator to move the picker along at least one of the x-, y-, or z-axes;
and
a mount to connect to the actuator to attach the picker and the driver to an imaging or detection system.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/248,510Filed 9 Apr 2014 · us provisional application

Priority

11 Apr 2013

Published

US 2014/0308163 A116 Oct 2014

Granted

13 Dec 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

G01N 1/14
In the liquid or fluent state: suction devices, e.g. pumps; Ejector devices
B01L 3/0217
Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids: of the plunger pump type
G01N 35/0098
Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor:…
G01N 35/1009
Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices: characterised by…

Device, system, and method for selecting a target analyte

Life of this patent

Device, system, and method for selecting a target analyte

Life of this patent

Abstract

Claims6