FKBP52-Tau interaction as a novel therapeutical target for treating the neurological disorders involving Tau dysfunction
AssigneeInstitut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsEtienne Baulieu, Beatrice Chambraud
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Abstract
Candidate compounds for use in neuro-protection and repair in neurological disorders involving Tau dysfunction (including Alzheimer's disease) are identified from a direct interaction between proteins FKBP52 and Tau. The method for screening a drug for the prevention and treatment of neurological disorders involving Tau dysfunction includes determining the ability of a candidate compound, to modulate binding between a Tau polypeptide and a FKBP52 polypeptide, and selecting positively the candidate compound that modulates binding.
Claims5
A method of diagnosing and treating a subject thought to have or be predisposed to having a neurological disorder involving Tau dysfunction, which comprises the steps of
- I) obtaining a sample of interest from said subject,
- II) measuring a concentration of the FKBP52 protein in the sample by using an antibody, an antibody derivative or an antibody fragment which binds specifically to the FKBP52 protein, and
- III) administering an effective amount of a compound which modulates a FKBP52 protein level in subjects having or being predisposed to having a neurological disorder involving Tau dysfunction so as to increase the FKBP52 protein level in the subjects.
Dependencies are inferred from the claim text.