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US 9,518,994 B2Granted
Method for diagnosing and monitoring schizophrenia and tauopathies
AssigneeRamot at Tel-Aviv University Ltd.
InventorsIllana Gozes, Efrat Dresner
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Abstract
The present invention provides methods and kits for diagnosing or monitoring conditions such as schizophrenia and tauopathies in a patient by determining the level of ADNP1 or ADNP2 in a sample from the patient.
Claims18
A method for assessing ADNP expression in a biological sample taken from a subject, comprising the steps of:
- (1) performing an assay to determine ADNP1 mRNA level in the sample;
- (2) performing an assay to determine ADNP2 mRNA level in the sample;
- and
- (3) calculating the ratio of the ADNP1 mRNA level obtained in step (1) to the ADNP2 mRNA level obtained in step (2), wherein each of steps (1) and (2) comprises performing a reverse transcriptase polymerase reaction (RT-PCR), and wherein the primer set of SEQ ID NO:
- 1 and SEQ ID NO:
- 2 is used in step (1).
3 more elements
A method for assessing ADNP expression in a biological sample taken from a subject, comprising the steps of:
- (1) performing an RT-PCR to determine ADNP1 mRNA level in the sample, wherein a primer of SEQ ID NO:1 or SEQ ID NO:2 is used in the PCR;
- (2) performing an RT-PCR to determine ADNP2 mRNA level in the sample;
- and
- (3) calculating the ratio of the ADNP1 mRNA level obtained in step (1) to the ADNP2 mRNA level obtained in step (2).
1 more element
Dependencies are inferred from the claim text.