Secernin-1 as a marker for cancer
AssigneeRoche Diagnostics Operations, Inc.
InventorsNorbert Wild, Marie-Luise Hagmann, Johann Karl, Julia Riedlinger, Markus Roessler, Michael Tacke
Life of this patent
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Abstract
Disclosed is a method aiding in the assessment of cancer. It involves the use of the secernin-1 protein (SCRN1) as a universal marker of different cancer types. More specifically disclosed is a method for assessing cancer from a liquid sample derived from an individual by measuring SCRN1 in the sample. Measurement of SCRN1 can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
Claims4
A method for in vitro assessment of a presence of cancer selected from the group consisting of lung, ovary, endometrial, melanoma, breast, head and neck, bladder, pancreas, cervix, kidney, and prostate cancer in a patient suspected of having cancer selected from the group consisting of lung, ovary, endometrial, melanoma, breast, head and neck, bladder, pancreas, cervix, kidney and prostate cancer, the method comprising
- a) detecting a full-length secernin-1 protein (SCRN1) in a body fluid sample from the patient by contacting, in vitro, the body fluid sample with an antibody that specifically binds to an epitope located in amino acids 398-413 of SEQ ID NO:1, wherein the antibody and the full-length SCRN1 form a complex;
- b) quantifying a signal from the complex to obtain a concentration of the full-length SCRN1 in the complex;
- c) analyzing the concentration of the full-length SCRN1 obtained in said step of quantifying to a SCRN1 reference concentration obtained from a normal control;
- and
- d) providing a diagnosis of the presence of cancer selected from the group consisting of lung, ovary, endometrium, melanoma, breast, head and neck, bladder, pancreas, cervix, kidney, and prostate cancer if the concentration of the full-length SCRN1 obtained in said step of quantifying is greater than the SCRN1 reference concentration obtained from the normal control.
Dependencies are inferred from the claim text.