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US 9,518,989 B2Granted
Composition and method for diagnosis and immunotherapy of lung cancer
AssigneeTexas Tech University System
InventorMaurizio Chiriva-Internati
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Abstract
The present invention includes compositions and methods for the diagnosis and treatment of lung cancer with a recombinant tumor-associated antigen loaded antigen presenting cell that generates a cytotoxic T lymphocyte specific immune response to at least one of SP17, AKAP-4, or PTTG1 expressed by one or more lung cancer cells.
Claims8
A composition for the treatment of lung cancer comprising:
- an isolated antigen presenting cell that has been loaded with an SP17 tumor associated antigen, an AKAP-4 antigen, and a PTTG1 antigen, wherein the antigen presenting cells activates cytotoxic T lymphocytes against the SP17 tumor associated antigen, the AKAP-4 antigen, and the PTTG1 antigen are expressed in the antigen presenting cells for presentation by Class I MHC, and the cytotoxic T lymphocytes kill one or more lung cancer cells that present one or more of the antigens.
Dependencies are inferred from the claim text.