Genetically encoded calcium indicators
AssigneeHoward Hughes Medical Institute
InventorsLoren Looger, Karel Svoboda, Douglas Kim, Rex Kerr
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Abstract
Genetically encoded calcium indicator (GECI) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of G-protein coupled receptor (GPCR) or ion channels and methods of monitoring neural activity also are provided.
Claims5
An isolated nucleic acid molecule encoding a genetically encoded calcium indicator (GECI) polypeptide, wherein the GECI polypeptide comprises an amino acid sequence having at least 99% sequence identity to the sequence as set forth in SEQ ID NO:
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Dependencies are inferred from the claim text.