Gamma 9 delta 2 T cell receptors

A medicament comprising one selected from the group consisting of:

• a) γ9δ2T-cell receptor, or fragment thereof, comprising:
• i) a γ9-T-cell receptor chain comprising a γ9-CDR3 region, wherein the amino acid sequence of the γ9-CDR3 region corresponding to amino acid residues 122-124 of SEQ ID NO. 1 is IQ (SEQ ID NO. 20) and a δ2-T-cell receptor chain comprising a δ2-CDR3 region wherein the amino acid sequence of the δ2-CDR3 region corresponding to amino acid residues 115-122 of SEQ ID NO. 2 is ALKRTD (SEQ ID NO. 15);
• or
• ii) a γ9-T-cell receptor chain comprising a γ9-CDR3 region, wherein the amino acid sequence of the γ9-CDR3 region corresponds to SEQ ID NO. 16 and a δ2-T-cell receptor chain comprising a δ2-CDR3 region wherein the amino acid sequence of the δ2-CDR3 region corresponds to SEQ ID NO. 17;
• b) a conjugate comprising a soluble fragment of the γ9δ2T-cell receptor, comprising the γ9-CDR3 and the δ2-T-cell δ2-CDR3 region, linked to an agent;
• c) an isolated nucleic acid sequence or isolated nucleic acid sequences encoding:
• i) the δ2-T-cell receptor chain, or fragment thereof, wherein the δ2-CDR3 region corresponding to amino acid residues 115-122 of SEQ ID NO. 2 is ALKRTD (SEQ ID NO. 15),
• ii) the γ9-T-cell receptor chain, or fragment thereof, wherein the amino acid sequence of the γ9-CDR3 region corresponding to amino acid residues 122-124 of the amino acid sequence of SEQ ID NO. 1 is IQ (SEQ ID NO. 20), or
• iii) the γ9δ2T-cell receptor, or fragment thereof;
• d) a genetic construct or genetic constructs comprising the isolated nucleic acid sequence(s);
• e) a retroviral vector or retroviral vectors comprising the genetic construct(s);
• and
• f) a T cell comprising the γ9δ2T-cell receptor.