Microfluidic assay apparatus and methods of use
AssigneeUniversity of Washington through its Center for Commercialization
InventorsAlbert Folch, Raymond J. Monnat, Chi-ting Chang, Lisa Horowitz, Christopher G. Sip, Robert C. Rostomily
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Abstract
Methods and microfluidic apparatus are disclosed for drug prediction. A microfluidic apparatus has (a) a plate, (b) a plurality of wells defined in the plate, (c) a plurality of closed microchannels defined in the plate, and (d) a sample platform defining a plurality of open microchannels, where the plurality of closed microchannels are each in communication with one of the plurality of wells and one of the plurality of open microchannels of the sample platform.
Claims18
A microfluidic apparatus, comprising:
- a plate;
- a plurality of wells defined in the plate;
- a plurality of closed microchannels defined in the plate, wherein each closed microchannel of the plurality of closed microchannels comprises a first portion and a second portion, wherein the first portion of each closed microchannel is defined at a higher level in the plate than the second portion of each closed microchannel;
- and
- a sample platform defining a plurality of open microchannels, wherein the plurality of closed microchannels are each in communication with one of the plurality of wells and one of the plurality of open microchannels of the sample platform.
A microfluidic apparatus, comprising:
- a plate;
- a plurality of wells defined in the plate;
- a plurality of closed microchannels defined in the plate;
- a sample platform defining a plurality of open microchannels, wherein the plurality of closed microchannels are each in communication with one of the plurality of wells and one of the plurality of open microchannels of the sample platform;
- and
- a removable porous membrane disposed on a top surface of the sample platform.
Dependencies are inferred from the claim text.