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US 9,518,972 B2Granted
Methods for detecting bacterial infections
AssigneesAvisa Pharma Inc., Southwest Sciences Incorporated
InventorsDavid S. Joseph, Steven M. Massick, Kristen A. Peterson, Anthony L. Gomez, Joel A. Silver
Life of this patent
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Abstract
The invention is directed to methods of detecting lung, gastrointestinal tract, and systemic infections by measuring 13CO2/12CO2 isotopic ratios of gaseous carbon dioxide in exhaled breath samples of a subject after administration of a 13C-isotopically-labeled compound.
Claims24
A method for determining the presence or absence of a bacterial lung infection in a subject comprising:
- administering to the subject, a 13C-isotopically-labeled compound that produces 13CO2 upon bacterial metabolism;
- collecting at least one sample of exhaled breath from the subject;
- conducting the sample to a sample chamber of a detection apparatus;
- actuating a laser light source of the detection apparatus to emit one or more of the wavelength pairs 2054.37 and 2052.42;
- 2054.96 and 2051.67;
- or 2760.53 and 2760.08 nanometers;
- directing the laser light thus actuated through the sample in the sample chamber to impinge upon a detector for such wavelengths;
- and
- ascertaining the isotopic ratio of 13CO2 to 12CO2 present in the sample to determine the presence or absence of a bacterial lung infection in the subject.
6 more elements
Dependencies are inferred from the claim text.