Method for identifying electrophiles and nucleophiles in a sample

A method for identifying a test molecule in a sample, said test molecule comprising an electrophilic or nucleophilic moiety, comprising:

• a) contacting said sample with a plurality of chemosensor molecules, each of said chemosensor molecules comprising a π-conjugated system and a moiety having a nucleophilic property or an electrophilic property;
• b) forming conjugate molecules according to a reaction of said plurality of said chemosensor molecules with said test molecule;
• and
• c) measuring an electromagnetic property of said conjugate molecules in the sample;
• whereby the pattern of changes in the electromagnetic properties of the plurality of conjugate molecules after chemically reacting with said electrophile or nucleophile of each test molecule identifies said test molecule in said sample;
• wherein said electromagnetic properties are selected from the group consisting of conduction, induction and dielectric property.

A method for detecting or identifying a test molecule in a sample, said test molecule comprising an electrophilic or nucleophilic moiety, comprising:

• a) contacting said sample with a plurality of chemosensor molecules, each of said chemosensor molecules comprising a π-conjugated system and a moiety having a nucleophilic property or an electrophilic property;
• b) if said plurality of said chemosensor molecules chemically reacts with said test molecule, forming conjugate molecules, said conjugate molecules having a structure determined at least partially according to a structure of said test molecule, wherein said test molecule is an alkylator, such that said conjugate molecule is formed through alkylation;
• and
• c) measuring an electromagnetic property of said conjugate molecules in the sample;
• whereby the pattern of changes in the electromagnetic properties of the plurality of conjugate molecules after chemically reacting with said electrophile or nucleophile of each test molecule identifies said test molecule in said sample;
• wherein said electromagnetic properties are selected from the group consisting of optical, conduction, induction and dielectric property.