DACH1 as a biomarker for diabetes
AssigneesThe Chinese University of Hong Kong, Hospital Authority
InventorsJuliana Chung-Ngor Chan, Wing-Yee So, Ronald Ching-Wan Ma
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Abstract
The present invention provides a method for assessing the presence and risk of developing type 2 diabetes or cardiovascular disease in a subject by detecting sequence variation in DACH1 (Dachshund homolog 1) gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating type 2 diabetes or cardiovascular disease in patients who have been tested and shown to have the pertinent genetic variations.
Claims11
A method for assessing the presence or risk of type 2 diabetes or cardiovascular disease in a human subject, comprising the steps of:
- (a) amplifying nucleotide sequence of a portion of genomic sequence of DACH1 (Dachshund homolog 1) present in a biological sample taken from the subject using primers consisting of SEQ ID NO:4 and SEQ ID NO:5,
- (b) detecting a T allele of polymorphism rs1408888 in the portion of genomic sequence of DACH1, and
- (c) determining that the subject has or is at risk of developing type 2 diabetes or cardiovascular disease.
Dependencies are inferred from the claim text.