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US 9,518,288 B2Granted
Methods and compositions related to quantitative, array based methylation analysis
AssigneeUniversity of Utah Research Foundation
InventorsAlexander M. Chagovetz, Steven M. Blair, Randy L. Jensen, Bryan J. Lowder
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Abstract
Disclosed are compositions and a method for detection of methylation based on quantitative arrays.
Claims18
A method of detecting methylation of a nucleic acid sample, the method comprising:
- a. exposing the nucleic acid sample to an array of oligonucleotide probes coupled to a solid substrate to form double-stranded duplexes;
- b. exposing the array of step a) to methyl binding domain (MBD) protein;
- and
- c. detecting interaction between the MBD protein and the double-stranded duplexes, wherein interaction indicates that the double-stranded duplexes are methylated.
1 more element
Dependencies are inferred from the claim text.