C5a binding nucleic acids
AssigneeNOXXON Pharma AG
InventorsKai Hohlig, Axel Vater, Klaus Buchner, Christian Maasch, Sven Klussmann
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Abstract
The present invention is related to a nucleic acid molecule capable of binding to human C5a, wherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central stretch of nucleotides comprises a nucleotide sequence of 5′ AUGn1GGUGKUn2n3RGGGHUGUKGGGn4Gn5CGACGCA 3′ [SEQ ID NO: 61], wherein n1 is U or dU, n2 is G or dG, n3 is A or dA, n4 is U or dU, n5 is U or dU and G, A, U, C, H, K, and R are ribonucleotides, and dU, dG and dA are 2′-deoxyribonucleotides.
Claims12
An L-nucleic acid that binds to human C5a or to mouse C5a, or a homolog of said L-nucleic acid, wherein said L-nucleic acid comprises the nucleic acid selected from the group consisting of SEQ ID NO:37 and SEQ ID NO:59, and the homolog has at least 85% homology to SEQ ID NO:37 or to SEQ ID NO:59.
Dependencies are inferred from the claim text.