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US 9,518,264 B2Granted
Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
AssigneeNogra Pharma Limited
InventorGiovanni Monteleone
Life of this patent
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Abstract
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment of chronic inflammatory bowel disease, such as Crohn's disease and ulcerative colitis.
Claims3
An antisense oligonucleotide against SMAD7 comprising SEQ ID NO:
- 9 (5′-YGCACXGAGTGXGTGAGZ-3′), wherein X is 5-methyl-2′-deoxycytidine 5′-monophosphate, Y is 2′-deoxyadenosine methylphosphonate, and Z is 2′-deoxycytidine methylphosphonate, or complements thereof.
Dependencies are inferred from the claim text.