US 9,518,251 B2Granted

Method for enhancing therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases

AssigneeGwo Xi Stem Cell Applied Technology Co., Ltd.

InventorsShinn-Zong Lin, Horng-Jyh Harn, Ru-Huei Fu, Shih-Ping Liu, Po-Cheng Lin, Ming-Hsi Chuang

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Abstract

A method for enhancing the therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises pre-treating the stem cells with ligustilide to increase the expression of differentiation-promoting genes in the stem cells, increase the expression of homing-promoting genes in the stem cells, and/or decrease the expression of inflammatory genes in the stem cells, wherein the treatment is conducted in a culture medium of the stem cell.

Claims16

Dependent claims

A method for enhancing the therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases, comprising:

a) pre-treating the stem cells by culturing the stem cells in a culture medium comprising 0.1 μg/ml to 20 μg/ml of ligustilide to increase the expression of differentiation-promoting genes in the stem cells, increase the expression of homing-promoting genes in the stem cells, and/or decrease the expression of inflammatory genes in the stem cells, wherein the culture medium does not comprise insulin;
and
b) administering an effective amount of stem cells pre-treated in step a) to a subject suffering from autoimmune diseases, cardiovascular diseases and/or hematological diseases.

Dependencies are inferred from the claim text.

Facts

Application: 15/074,490Filed 18 Mar 2016 · division
Priority: TW 103132044 A17 Sep 2014
Published: US 2016/0075999 A121 Jul 2016
Granted: 13 Dec 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification21 codes

A61K 35/28
Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically…:…
A61K 31/365
Having oxygen as the only ring hetero atom, e.g. fungichromin: lactones
A61K 35/545
Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells: embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells;…
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system

Family

Application14/552,014Parent of this division · filed 24 Nov 2014
Application14/821,309Parent of this division · filed 7 Aug 2015
US 2016/0208217 A1Pre-grant publication · published 21 Jul 2016
US 2016/0075999 A1Published application
US 2016/0303168 A1Published application
US 9,523,081 B2Related patent
US 9,533,012 B2Related patent
US 9,518,251 B2This patent

From the US filing history. Foreign family members aren’t listed.

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