US 9,518,250 B2 · Method for the ex vivo expansion of hematopoietic stem and progenitor cells

Abstract

The present invention relates to hematopoietic cells, and more specifically to methods for long-term in vitro culturing and ex vivo expansion of hematopoietic cells. The present invention also provides compositions useful for culturing cells, such as media for culturing hematopoietic cells, specifically haematopoietic stem cells (HSC) and haematopoietic progenitor cells (HPC). The present invention further provides compositions including growth factor combinations and methods utilizing altered growth and environmental conditions that are applicable in vitro culturing and to ex vivo expansion of HSC and/or HPC.

Claims14

Dependent claims

A method of extending ex vivo viability of a HPC and/or HSC population, or culturing or expanding a HPC and/or HSC population said method comprising culturing the HPC and/or HSC population in the presence of at least one of ficolin-1, ficolin-2, or ficolin-3.

Dependencies are inferred from the claim text.

Facts

Application

14/346,160Filed 21 Sep 2012

Priority

AU 201190389922 Sep 2011

Published

US 2014/0286915 A125 Sep 2014

Granted

13 Dec 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C12N 5/0647
Cells from the blood or the immune system: haematopoietic stem cells; Uncommitted or multipotent progenitors
A61P 7/00
Drugs for disorders of the blood or the extracellular fluid
C12N 2501/125
Growth factors: stem cell factor [SCF], c-kit ligand [KL]
C12N 2501/145
Growth factors: thrombopoietin [TPO]

Method for the ex vivo expansion of hematopoietic stem and progenitor cells

Life of this patent

Method for the ex vivo expansion of hematopoietic stem and progenitor cells

Life of this patent

Abstract

Claims14