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US 9,518,129 B2Granted
Thrombin-binding antibody molecules and uses thereof
AssigneeJanssen Pharmaceuticals, Inc.
InventorsJames Andrew Huntington, Trevor Baglin, Jonathan Langdown
Life of this patent
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Abstract
This invention relates to isolated antibodies which recognize the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding. These antibody molecules may be useful in the treatment and prevention of thrombosis, embolism and other conditions mediated by thrombin.
Claims25
A recombinant antibody molecule, comprising a VH domain having the amino acid sequence of SEQ ID NO:
- 2, a VL domain, and an IgG constant region, wherein the recombinant antibody molecule specifically binds to the exosite 1 region of thrombin.
A recombinant antibody molecule, comprising a VH domain comprising
- an HCDR3 having the amino acid sequence of SEQ ID NO:
- 5,
- an HCDR2 having the amino acid sequence of SEQ ID NO:
- 4, and
- an HCDR1 having the amino acid sequence of SEQ ID NO:
- 3,
- a VL domain comprising an LCDR1 having the amino acid sequence of SEQ ID NO:
- 7 or the amino acid sequence of SEQ ID NO:
- 7 with one or two amino acid substitutions, an LCDR2 having the amino acid sequence of SEQ ID NO:
- 8, and an LCDR3 having the amino acid sequence of SEQ ID NO:
- 9, and an IgG constant region, wherein the recombinant antibody molecule specifically binds to the exosite 1 region of thrombin.
8 more elements
Dependencies are inferred from the claim text.