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US 9,518,122 B2Granted
Endoglin antibodies
AssigneeTracon Pharmaceuticals, Inc.
InventorsCharles Theuer, Maximiliano Vasquez
Life of this patent
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AssigneeTracon Pharmaceuticals, Inc.
InventorsCharles Theuer, Maximiliano Vasquez
Estimating the term…
The present application relates to compositions of humanized and humanized/deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One aspect relates to antibodies having one or more modifications in at least one amino acid residue of at least one of the framework regions of the variable heavy chain, the variable light chain or both. Another aspect relates to antibodies which bind endoglin and inhibit angiogenesis. Another aspect relates to the deimmunization of humanized antibodies to reduce immunogenicity. Another aspect relates to the use of humanized and humanized/deimmunized antibodies which bind endoglin for the detection, diagnosis or treatment of a disease or condition associated with endoglin, angiogenesis or a combination thereof.
A method of treating an ocular condition that is choroidal neovascularization (CNV), diabetic nephropathy, non-diabetic retinopathy, sub-retinal neovascularization, proliferative vitreoretinopathy, or a neovascular glaucoma in a subject in need thereof, comprising administering to the subject a composition comprising an antibody or antigen-binding fragment thereof, that binds endoglin, wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region having an amino acid sequence set forth as SEQ ID NO:
A method of treating choroidal neovascularization (CNV) in a subject in need thereof, comprising administering to the subject a composition comprising an antibody or antigen-binding fragment thereof, that binds endoglin, wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region having the amino acid sequence set forth as SEQ ID NO:
A method of treating a chronic inflammatory disease in a subject in need thereof, comprising administering to the subject a composition comprising an antibody or antigen-binding fragment thereof, that binds endoglin, wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region having an amino acid sequence set forth as SEQ ID NO:
A method of treating a chronic inflammatory disease in a subject in need thereof, comprising administering to the subject a composition comprising an antibody or antigen-binding fragment thereof, that binds endoglin, wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region having the amino acid sequence set forth as SEQ ID NO:
Dependencies are inferred from the claim text.