Anti-CXCR4 antibody and its use for the detection and diagnosis of cancer
AssigneePierrre Fabre Medicament
InventorsChristine Klinguer-Hamour, Alexandra Jouhanneaud, Marie-Claire Janin-Bussat
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Abstract
The present invention provides a novel, isolated anti-CXCR4 antibody for use in the diagnosis of cancer. In particular, the antibody of the invention recognizes monomeric and homodimeric CXCR4, but not heterodimeric CXCR4.
Claims17
An anti-CXCR4 antibody, or a CXCR4-binding fragment thereof, comprising i) a heavy chain comprising the following three CDRs, respectively CDR-H1 having the sequence SEQ ID No. 1, CDR-H2 having the sequence SEQ ID No. 2, and CDR-H3 having the sequence SEQ ID No. 3;
- and ii) a light chain comprising the following three CDRs, respectively CDR-L1 having the sequence SEQ ID No. 4, CDR-L2 having the sequence SEQ ID No. 5, and CDR-L3 having the sequence SEQ ID No. 6.
A murine hybridoma capable of secreting an antibody or a CXCR4-binding fragment thereof, said murine hybridoma being deposited at the CNCM, Institut Pasteur, Paris, France on Jun. 25, 2008 under the number I-4018.
Dependencies are inferred from the claim text.