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AssigneeSt. Jude Children's Research Hospital
InventorsDario Vignali, Creg Workman, Lauren Collison, Kate Vignali
Estimating the term…
Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
A pharmaceutical composition comprising an excipient and an isolated human or humanized monoclonal antibody or antigen-binding fragment thereof capable of binding human Interleukin 35 (IL35) heterodimer, wherein the antibody is present in the composition in an amount effective to inhibit a regulatory T- cell function in a human subject to whom the composition is administered.
A monoclonal antibody that specifically binds to human IL35.
Dependencies are inferred from the claim text.