Antibody preparations

A method of treatment of a patient suffering from a bacterial infection comprising administering an antibody preparation intravenously to said patient wherein the antibody preparation comprising:

• IgG, IgA and at least 5% IgM antibodies by weight of the total amount of antibodies;
• wherein the preparation is prepared from human plasma;
• wherein the antibody preparation is prepared by a process which is capable of a more than 3 log10 removal of non-enveloped viruses;
• wherein the antibody preparation has specific complement activating activity;
• and wherein, in an in vitro assay with human serum suitable to determine the ability of the antibody preparation to activate complement unspecifically, the antibody preparation generates:
• (i) substantially no C5a, such that the antibody preparation, adjusted to an IgM concentration of 1.72 mg/ml, generates less than 200 ng/ml C5a after 60 minutes of the assay and/or (ii) substantially no C3a, such that the antibody preparation, adjusted to an IgM concentration of 1.72 mg/ml, generates less than 6000 ng/ml C3a after 60 minutes of the assay.