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US 9,518,094 B2Granted
Romidepsin solid forms and uses thereof
AssigneeCelgene Corporation
InventorsJason Hanko, David Alan Engers, Eric Hagen, Valeriya Smolenskaya, Jeffrey Scott Stults
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Abstract
The present disclosure provides solid forms of a compound of formula I. In some embodiments, the present disclosure provides crystalline forms of Compound I. In some embodiments, the present disclosure provides solvate forms of Compound I. In some embodiments, the present disclosure provides amorphous Compound I.
Claims6
A crystalline form of romidepsin characterized by:
- XRPD characteristic peaks at about 9.0 2θ, 10.3 2θ, 11.7 2θ, and 20.4 2θ;
- a differential scanning calorimetry (DSC) thermogram having endotherm at ˜255° C.;
- or
- a thermogravimetric analysis (TGA) thermogram exhibiting a weight loss of ˜10.9%.
1 more element
Dependencies are inferred from the claim text.