Back to results
US 9,518,091 B2Granted
A4B7 peptide monomer and dimer antagonists
AssigneeProtagonist Therapeutics, Inc.
InventorsAshok Bhandari, Dinesh V. Patel, Genet Zemede, Larry C. Mattheakis, David Liu
Life of this patent
Estimating the term…
Abstract
The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, possess high selectivity against α4β1 binding, and have high stability under gastrointestinal conditions.
Claims21
A peptide comprising the amino acid sequence:
- Pen-(N-Me-Arg)-Ser-Asp-Thr-Leu-Pen-Phe(4-tBu)-(β-homo-Glu)-(D-Lys).
A peptide dimer compound comprising two peptides, each peptide comprising the amino acid sequence:
- Pen-(N-Me-Arg)-Ser-Asp-Thr-Leu-Pen-Phe(4-tBu)-(β-homo-Glu)-(D-Lys), or a pharmaceutically acceptable salt thereof,
- wherein the two peptides are linked by a linker moiety.
Dependencies are inferred from the claim text.