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US 9,518,090 B2Granted
Compositions and methods for treating hepatitis B
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsDing Xue, Xin Geng
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AssigneeThe Regents of the University of Colorado, a body corporate
InventorsDing Xue, Xin Geng
Estimating the term…
The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.
A method for treating hepatitis B infection in a subject, said method comprising administering to a subject in need of such a treatment a composition (i) that is capable of inhibiting binding of hepatitis B virus X protein to a Bcl-2 family member protein in said subject;
A method for identifying a composition that is capable of treating hepatitis B virus (HBV) infection in a mammal, said method comprising determining the effect of said composition in an interaction between HBV X protein and CED-9 protein of C. elegans, wherein modulation of the interaction between HBV X protein and CED-9 protein in the presence of said composition is an indication that said composition is capable of treating HBV infection in a mammal.
A method for treating hepatitis B infection in a subject, said method comprising administering to a subject in need of such a treatment a therapeutically effective amount of a composition comprising peptaibol TK.
Dependencies are inferred from the claim text.