Metallothionein-derived peptide fragments
AssigneeUniversity of Tasmania
InventorsVladimir Berezin, Elisabeth Bock, Milena Penkowa
Life of this patent
Estimating the term…
Abstract
The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
Claims11
A peptide consisting of not more than 17 amino acids, wherein the peptide comprises the amino acid sequence SAGSCKCKESKSTS (SEQ ID NO:7) or a variant of SEQ ID NO:7, said variant having at least 90% sequence identity to SEQ ID NO:7, and wherein the peptide stimulates neurite outgrowth, neural cell survival, neural cell differentiation, and/or neural plasticity associated with learning and memory, and/or inhibits inflammation.
A compound comprising one or more peptides, wherein each of said one or more peptides consists of not more than 17 amino acids, wherein each of said one or more peptides comprises the amino acid sequence SAGSCKCKESKSTS (SEQ ID NO:7) or a variant of SEQ ID NO:7, said variant having at least 90% sequence identity to SEQ ID NO:7, and wherein each of said peptides stimulates neurite outgrowth, neural cell survival, neural cell differentiation, and/or neural plasticity associated with learning and memory, and/or inhibits inflammation.
A pharmaceutical composition comprising a peptide consisting of not more than 20 amino acids, wherein the peptide comprises the amino acid sequence SAGSCKCKESKSTS (SEQ ID NO:7) or a variant of SEQ ID NO:7, said variant having at least 90% sequence identity to SEQ ID NO:7, and wherein the peptide stimulates neurite outgrowth, neural cell survival, neural cell differentiation, and/or neural plasticity associated with learning and memory, and/or inhibits inflammation.
Dependencies are inferred from the claim text.