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US 9,518,081 B2Granted
Peptide libraries
AssigneeBicycle Therapeutics Limited
InventorsGregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, Daniel Paul Teufel
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AssigneeBicycle Therapeutics Limited
InventorsGregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, Daniel Paul Teufel
Estimating the term…
The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c).
A method for altering the conformation of a first polypeptide ligand or group of polypeptide ligands, wherein each polypeptide ligand comprises at least three reactive groups each separated by a loop sequence and wherein the at least three reactive groups are linked to a molecular scaffold which forms covalent bonds with the at least three reactive groups, to produce a second polypeptide ligand or group of polypeptide ligands, comprising assembling the second ligand or group of ligands from the polypeptide(s) and molecular scaffold of the first ligand or group of ligands by altering at least one of the three reactive groups to cysteine, selenocysteine or methionine.
Dependencies are inferred from the claim text.