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US 9,518,077 B2Granted
Electrochemical synthesis of chloro-chitosan
AssigneeThe Research Foundation for The State University of New York
InventorsGary P. Halada, Prashant Kumar Jha
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Abstract
The present disclosure provides methods for producing chitosan derivatives and the derivatives formed by these methods. The processes of the present disclosure utilize electrochemical methods to functionalize and/or modify amine and/or hydroxyl groups present on chitosan, to form new derivatives. In embodiments, a chloro-chitosan derivative may be prepared. The altered cationic affinity of these derivatives make them excellent candidates for biomedical applications, including pharmaceuticals, as well as food applications.
Claims5
A process comprising:
- contacting chitosan with a solvent selected from the group consisting of water, alcohols and combinations thereof, with heating to a temperature from about 25° C. to about 70° C. to form a chitosan solution having chitosan present in an amount from about 1% to about 10% by weight of the solution;
- adding to the chitosan solution an acid selected from the group consisting of hydrochloric acid, hypochlorous acid, and combinations thereof, to reduce the pH of the chitosan solution to a pH from about 1 to about 6;
- applying a positive potential of from about 1.5 volts to about 50 volts to the chitosan solution by the introduction of a cathode and anode into the chitosan solution;
- forming a chloro-chitosan as a froth in the chitosan solution;
- and
- recovering the chloro-chitosan from the froth of the chitosan solution, wherein the chloro-chitosan includes a monomer of the following formula:
3 more elements
Dependencies are inferred from the claim text.