Inhibitor crystalline form and preparation method and use thereof
AssigneeHangzhou Pushai Pharmaceutical Technology Co., Ltd.
InventorsZhonghua Zhang, Xiaoxia Sheng, Xiaohong Sheng
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Abstract
The present invention relates to new crystalline forms of the inhibitor, 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazoline-4-one; the present invention also relates to methods for preparing the new crystalline forms of 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazolin-4-one, pharmaceutical compositions containing the new crystalline forms thereof, and uses thereof for the treatment and/or prevention of diseases such as chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma.
Claims28
A crystal Form IX of Idelalisib with the structural formula shown below,
- wherein, Form IX is a hydrate with 0.7 molecule of water;
- and Form IX is characterized by a X-ray powder diffraction pattern measured using Cu-Kα radiation, expressed as 2θ angles, having the following characteristic peaks:
- 8.8±0.2°, 11.0±0.2°, 13.9±0.2°, 14.9±0.2°, 16.2±0.2° and 20.6±0.2°.
A crystal Form IV of Idelalisib with the structural formula shown below,
- wherein, Form IV is characterized by a X-ray powder diffraction pattern measured using Cu-Kα radiation, expressed as 2θ angles, having the following characteristic peaks:
- 7.8±0.2°, 9.2±0.2° 14.1±0.2°, 15.7±0.2°, 17.7±0.2°, 18.9±0.2° and 20.7±0.2°.
A crystal Form VI of Idelalisib with the structural formula shown below,
- wherein, Form VI is a tetrahydrate, and Form VI is characterized by a X-ray powder diffraction pattern measured using Cu-Kα radiation, expressed as 2θ angles, having the following characteristic peaks:
- 9.8±0.2°, 11.3±0.2°, 13.3±0.2°, 17.5±0.2°, 19.3±0.2° and 23.2±0.2°.
A crystal Form III of Idelalisib with the structural formula shown below,
- wherein, Form III is characterized by a X-ray powder diffraction pattern measured using Cu-Kα radiation, expressed as 2θ angles, having the following characteristic peaks:
- 9.3±0.2°, 12.8±0.2°, 14.2±0.2°, 15.9±0.2°, 18.1±0.2° and 18.8±0.2°.
Dependencies are inferred from the claim text.