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US 9,518,057 B2Granted
Derivatives and methods of treating hepatitis B infections
AssigneeNovira Therapeutics, Inc.
InventorsGeorge D. Hartman, Scott Kuduk
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
Claims20
A compound having the structure of Formula III:
- or a pharmaceutically acceptable salt thereof, wherein
- Y is —C(O)—;
- R1 is C3-C8-cycloalkyl or C2-C8-heterocyclyl, wherein cycloalkyl and heterocyclyl are optionally substituted with 1 or 2 groups each independently selected from —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
- R2 is, at each occurrence, independently selected from H, —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
- R3 is selected from H, —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
- R4 is selected from (CR8R9)p—C1-C9-heteroaryl and (CR8R9)p—C6-C12-aryl, wherein heteroaryl and aryl are optionally substituted with 1, 2, or 3 groups, each independently selected from —OH, halo, CN, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
- R7 is selected from H, C1-C6-alkyl, and C1-C6-alkyl-OH;
- R8 is, at each occurrence, independently selected from H, —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
- R9 is, at each occurrence, independently selected from H and C1-C6-alkyl;
- and
- p is 0, 1, 2, 3, or 4.
8 more elements
Dependencies are inferred from the claim text.