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US 9,518,051 B2Granted
Pyrroloquinoline alkaloids as antimalarial agents and process for the preparation thereof
AssigneeCouncil of Scientific and Industrial Research
InventorsSantosh Baburao Mhaske, Jyoti Reveji Lande
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Abstract
The patent provides novel compounds with potential anti-malarial activity and process of synthesis thereof. Further, the process for the synthesis of known antimalarial natural products marinoquinazolinone A-F, aplidiopsamine A and their potential antimalarial analogs is disclosed.
Claims10
A compound of formula I or a pharmaceutically acceptable salt thereof,
- wherein R, R1, and R2 are selected from the group consisting of H, halide, alkyl, aryl, hetero alkyl, and hetero aryl,
- X is H, halide, OTf, or OTs,
- R3 is a compound of formula III,
- and
- R4 is selected from the group consisting of H, halide, alkyl, aryl, hetero alkyl, and hetero aryl.
2 more elements
A method of treating malaria comprising the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof,
- wherein R, R1, and R2 are selected from the group consisting of H, halide, alkyl, aryl, hetero alkyl, and hetero aryl,
- X is H, halide, OTf, or OTs,
- R3 is a compound of formula III, and
- R4 is selected from the group consisting of H, halide, alkyl, aryl, hetero alkyl, and hetero aryl.
1 more element
Dependencies are inferred from the claim text.