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US 9,518,044 B2Granted
Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto
AssigneeEmory University
InventorsJianxiong Jiang, Thota Ganesh, Yuhong Du, Pahk Thepchatri, Yi Quan, Ray J. Dingledine
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Abstract
The present invention is directed to compounds of Formula IC: wherein the substituents are described herein. These compounds and their pharmaceutically acceptable salts thereof are prostaglandin receptor EP2 antagonists.
Claims3
A pharmaceutical composition comprising a compound of Formula IC,
- or pharmaceutically acceptable salt or prodrug thereof, wherein:
- W is CH or N;
- n is 1, 2, 3, or 4;
- Y1, Y2, Y3, Y4, and Y5 are each, the same or different, hydrogen, alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl)2amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl;
- X1, X2, X3, and X4 are each, the same or different, hydrogen, alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl)2amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl;
- X5 is alkyl, wherein X5 is optionally substituted with one or more, the same or different, halogen.
3 more elements
Dependencies are inferred from the claim text.