US 9,518,038 B2 · Condensation product of theanine derivative and carboxylic acid coumarin derivative, its intermediate, preparation method and use thereof

Abstract

The present invention relates to a compound as represented by formula (I), which is a condensation product of a theanine derivative and a carboxylic acid coumarin derivative, compounds as represented by formula (II) and formula (III), both of which are intermediates of the condensation product, a method for preparing these compounds, a pharmaceutical composition comprising the compounds, and a use thereof in preparing a medicament for prevention and treatment of tumors, inflammation, cardiovascular diseases, immune deficiency diseases and the like. Wherein, (Ia) R═CH3 R1═H R2═H (Ib) R═CH2CH3 R1═H R2═H (Ic) R═CH2CH3 R1═Cl R2═H (Id) R═CH2CH3 R1═Br R2═H (Ie) R═CH2CH3 R1═F R2═H (If) R═CH2CH3 R1═NO2 R2═H (Ig) R═CH2CH3 R1═Cl R2═Cl (Ih) R═CH2CH3 R1═Br R2═Br (Ii) R═CH2CH3 R1═NH2 R2═H Wherein, (IIa) R═CH3 (IIb) R═CH2CH3 Wherein, (IIIc) R1═Cl R2═H (IIId) R1═Br R2═H (IIIe) R1═F R2═H (IIIf) R1═NO2 R2═H (IIIg) R1═Cl R2═Cl (IIIh) R1═Br R2═Br

Claims9

Dependent claims

A compound as represented by formula (I):

wherein Formula (I) has variables and bonds selected from (Ib) to (Ii), wherein;
R=CH2CH3, and
(Ib) R1=H, R2=H and =;
(Ic) R1=Cl, R2=H and =;
(Id) R1=Br, R2=H and =;
(Ie) R1=F, R2=H and =;
(If) R1=NO2, R2=H and =;
(Ig) R1=Cl, R2=Cl and =;
(Ih) R1=Br, R2=Br and =;
or
(Ii) R1=NH2, R2=H and =.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/431,707Filed 25 Sep 2013

Priority

CN 2012 1 036336627 Sep 2012

Published

US 2015/0239861 A127 Aug 2015

Granted

13 Dec 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification19 codes

C07D 311/12
Not hydrogenated in the hetero ring: substituted in position 3 and unsubstituted in position 7
A61K 31/223
Of acyclic acids, e.g. pravastatin: of alpha-aminoacids
A61K 31/37
Having six-membered rings, e.g. delta-lactones: coumarins, e.g. psoralen
A61K 49/0039
The fluorescent group being a small organic molecule: coumarin dyes

Condensation product of theanine derivative and carboxylic acid coumarin derivative, its intermediate, preparation method and use thereof

Life of this patent

Condensation product of theanine derivative and carboxylic acid coumarin derivative, its intermediate, preparation method and use thereof

Life of this patent

Abstract

Claims9