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US 9,518,032 B2Granted
Small molecule inhibitors of USP1 deubiquitinating enzyme activity
AssigneesDana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc.
InventorsAlan D. D'Andrea, Gregory D. Cuny, Ross L. Stein, Marcie Glicksman, April Case, Jun Xian, David Wilson, Min Huang
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Abstract
Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.
Claims3
A pharmaceutical composition comprising:
- a small molecule inhibitor of ubiquitin specific protease 1 (USP1) of Formula IV (527):
- or a pharmaceutically acceptable salt thereof;
- and
- a DNA cross-linking agent.
1 more element
A pharmaceutical composition comprising:
- a small molecule inhibitor of ubiquitin specific protease 1 (USP1) of Formula IV (527):
- or a pharmaceutically acceptable salt thereof;
- and
- a poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) inhibitor.
1 more element
Dependencies are inferred from the claim text.