US 9,518,008 B2Granted

(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-uanidino-2-hydroxyl-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof

AssigneeInstitute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

InventorsSong Li, Wu Zhong, Zhibing Zheng, Xinbo Zhou, Junhai Xiao, Yunde Xie, Lili Wang, Xingzhou Li, Guoming Zhao, Xiaokui Wang, Hongying Liu

Life of this patent

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Abstract

The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.

Claims17

Dependent claims

A compound of the general formula (I):

wherein X is 3.0.

Dependencies are inferred from the claim text.

Facts

Application: 14/511,783Filed 10 Oct 2014 · continuation
Priority: CN 2007 1 014360714 Aug 2007
Published: US 2015/0133556 A114 May 2015
Granted: 13 Dec 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07C 279/16
Derivatives of guanidine, i.e. compounds containing the group [IMAGE cpc-sch-C07C-0970.gif], the singly-bound nitrogen atoms not being part of…:…
A61P 11/00
Drugs for disorders of the respiratory system
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
A61P 31/16
For RNA viruses: for influenza or rhinoviruses

Family

PCT/CN2008/001459Parent of this continuation · filed 13 Aug 2008
US 2015/0133556 A1Pre-grant publication · published 14 May 2015
Application12/673,355Parent of this continuation
US 2011/0065795 A1Published application
US 9,518,008 B2This patent

From the US filing history. Foreign family members aren’t listed.