Antagonists of the toll-like receptor 1/2 complex
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsHang Yin, Kui Cheng
Life of this patent
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Abstract
Provided are compounds, compositions and methods for treating Toll-like receptor 1/2 complex (TLRI/2) related inflammatory disorders. Small molecules, based on the benzotropolone scaffold, capable of influencing downstream signaling are disclosed as well as methods of making and modifying these molecules. Also provided are methods for treating a subject for a clinical condition associated with Toll-like receptor complex 1/2 activation, comprising administering to the subject an effective amount of a benzotropolone compound.
Claims8
A compound having the chemical structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the chemical structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the chemical structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the chemical structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the chemical structure:
- or a pharmaceutically acceptable salt thereof.
A compound having the chemical structure:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.