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US 9,517,598 B2Granted
Method for making self-assembling, collagen-based material for corneal replacement
AssigneeUniversity of South Florida
InventorsW. Garrett Matthews, August Heim, Thomas J. Koob
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Abstract
A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into orthogonal stacks of lamellae comprised of aligned fibrils. The resulting structure is a transparent film of arbitrary thickness very similar in structure to mammalian corneal tissue.
Claims9
A method for producing a material suitable for ophthalmic purposes, comprising:
- obtaining collagen fibrils;
- and
- forming the collagen fibrils into a transparent film,
- wherein forming the collagen fibrils into a transparent film comprises:
- centrifuging an aqueous preparation of the collagen fibrils to obtain a pellet of the collagen fibrils;
- and
- lyophilizing the pellet on a template, thereby forming the transparent film on the template.
4 more elements
Dependencies are inferred from the claim text.