2-alkoxy-11-hydroxyaporphine derivatives and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein
• X1 is 2-fluoroethyl, 3-fluoro-n-propyl, 2-iodoethyl, or 3-iodo-n-propyl;
• R1 is H, CH3, CH2CH3, or CH2CH2CH3;
• R2 is H or OY2;
• each of Y1 and Y2 is, independently, selected from H, C(O)—R3, and fatty acid acyl, and
• R3 is selected from H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, and C1-7 heteroalkyl,
• wherein said compound has an in vitro affinity of between 0.5 nM and 35 nM at D2high receptors.