Back to results
US 9,517,275 B2Granted
Targeted therapy for the prevention of restenosis in the cardiovascular system
AssigneeNorthwestern University
InventorsMelina R. Kibbe, Samuel I. Stupp, Tyson J. Moyer, Edward Moreira Bahnson
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions and methods for targeted drug delivery to prevent restenosis in the cardiovascular system. In particular, provided herein are nanoscale delivery vehicles for drugs that prevent proliferation and neointimal hyperplasia.
Claims21
A peptide amphiphile comprising:
- (a) a hydrophobic non-peptidic segment;
- (b) a β-sheet-forming peptide segment;
- (c) a charged peptide segment;
- (d) a targeting moiety, wherein the targeting moiety comprises a binding sequence for collagen IV and comprises a 6 amino acid segment with at least 50% sequence identity with KLVWLPK (SEQ ID NO:
- 2);
- and
- (e) a therapeutic agent;
- wherein the hydrophobic non-peptidic segment is covalently attached to the N-terminus of the β-sheet-forming peptide segment;
- wherein the C-terminus of the β-sheet-forming peptide segment is covalently attached to the N-terminus of the charged peptide segment;
- and
- wherein the C-terminus of the charged peptide segment is covalently attached to the N-terminus of the targeting moiety.
8 more elements
A peptide amphiphile comprising:
- (a) a hydrophobic non-peptidic segment comprising a (CH2)12 tail;
- (b) a peptide portion with at least 50% sequence identity with KLVWLPKCK2A2V2K (SEQ ID NO:
- 1);
- and
- (c) a therapeutic agent;
- wherein the hydrophobic non-peptidic segment is covalently attached to the N-terminus of the peptide portion.
3 more elements
Dependencies are inferred from the claim text.