Photodynamic diagnostic agent and photobleaching inhibitor
AssigneesSBI Pharmaceuticals Co., Ltd., Tokyo Institute of Technology
InventorsMasahiro Ishizuka, Tohru Tanaka, Shun-ichiro Ogura, Takuya Ishii
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Abstract
The objects of the present invention are to inhibit photobleaching of porphyrins as well as to provide a superior photodynamic diagnostic agent and a photodynamic diagnostic method employing the photobleaching inhibitor for porphyrins. The present invention provides a photodynamic diagnostic agent containing a precursor of porphyrins and a gallic acid. The present invention also provides a photobleaching inhibitor for porphyrins containing a gallic acid.
Claims12
A method for detecting a porphyrin accumulation site, comprising:
- irradiating a subject with the excitation light for porphyrins, wherein said subject has been administered in advance of said irradiation a precursor of porphyrins and a compound of the following formula (I):
- wherein R1 is selected from the group consisting of an alkyl group having 1-10 carbons, a cycloalkyl group having 3-8 carbons, an aryl group having 6-14 carbons, and an aralkyl group having 7-15 carbons, and R2, R3, and R4 each represent a hydroxyl group,
- or a salt thereof, said precursor of porphyrins and compound of formula (I) having been administered to said subject at simultaneous or different times, and
- detecting the fluorescence of porphyrins, thereby detecting the porphyrin accumulation site.
A photodynamic diagnostic method for measuring a range of a lesion site in a subject, comprising:
- administering to said subject a precursor of porphyrins and a compound of the following formula (I):
- wherein R1 is selected from the group consisting of an alkyl group having 1-10 carbons, a cycloalkyl group having 3-8 carbons, an aryl group having 6-14 carbons, and an aralkyl group having 7-15 carbons, and R2, R3, and R4 each represent a hydroxyl group
- or a salt thereof, at simultaneous or different times,
- irradiating the subject with the excitation light for porphyrins,
- identifying the porphyrins accumulation site by detecting the fluorescence of porphyrins, and
- measuring the range of the lesion site.
Dependencies are inferred from the claim text.