Liquid formulation containing a protein drug
AssigneeSamsung Electronics Co., Ltd.
InventorsIn Hwan Lim, Dong Uk Kim, Geun Woong Kim, Hee Kyung Sung, Yun Ju Jeong
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Abstract
Disclosed is a method of preparing a stabilized liquid formulation of a protein drug, comprising admixing a protein drug with a composition for stabilization, wherein the composition for stabilization comprises a surfactant, a buffer, and a liquid medium, and has a pH from about 5 to about 8.
Claims13
A method for stabilizing a protein drug, comprising admixing a protein drug with a composition for stabilization, wherein the composition for stabilization comprises a surfactant, a buffer, and a liquid medium, and has a pH from about 5 to about 8, wherein the protein drug is an anti-c-Met antibody or antigen-binding fragment thereof comprising a CDR-H1 comprising SEQ ID NO:
- 1, a CDR-H2 comprising SEQ ID NO:
- 2, a CDR-H3 comprising SEQ ID NO:
- 3, a CDR-L1 comprising SEQ ID NO:
- 10, a CDR-L2 comprising SEQ ID NO:
- 11, and a CDR-L3 comprising SEQ ID NO:
- 13;
- and the buffer comprises succinic acid, citric acid, or a combination thereof.
Dependencies are inferred from the claim text.