Methods for the prevention and/or treatment of memory impairment
AssigneeThe Governing Council of the University of Toronto
InventorBeverley A. Orser
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Abstract
The present invention relates to methods for the prevention and/or treatment of memory impairment and for improving memory and particularly to methods for the prevention and/or treatment of memory impairment and improving memory comprising administering an agent that decreases activity of a GABAA receptor. The present invention also relates the use of an agent that decreases activity of a GABAA receptor for preventing or treating a memory deficit and for improving memory.
Claims30
A method for attenuating and/or treating a persistent memory deficit, comprising administering a benzodiazepine site inverse agonist, wherein the memory deficit is induced by inflammation and/or administration of an anesthetic selected from the group consisting of isoflurane, sevoflurane, desflurane, etomidate and propofol.
A method for attenuating a persistent memory deficit induced by an anesthetic in a subject to be treated with the anesthetic, the method comprising administering a benzodiazepine site inverse agonist prior to or with the anesthetic to prevent the anesthesia-induced memory deficit, wherein the subject is at risk for a post-anesthetic cognitive deficit and wherein the anesthetic is selected from the group consisting of isoflurane, sevoflurane, desflurane, etomidate and propofol.
A method for treating a persistent memory deficit induced by an anesthetic in a subject having been treated with the anesthetic, the method comprising administering a benzodiazepine site inverse agonist to treat the anesthesia-induced memory deficit, wherein the subject is experiencing a post-anesthetic cognitive deficit and wherein the anesthetic is selected from the group consisting of isoflurane, sevoflurane, desflurane, etomidate and propofol.
Dependencies are inferred from the claim text.