Benzonaphthyridine-containing vaccines
AssigneeGlaxosmithkline Biologicals SA
InventorsDerek O'Hagan, Manmohan Singh, Siddhartha Jain, Sushma Kommareddy
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Abstract
The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
Claims41
An immunogenic composition comprising (a) a first antigen, (b) polymeric particles that comprise a polymer that is at least partially biodegradable wherein said polymer comprises a polymer block selected from a polyester block, a polyorthoester block, and a polyanhydride block, and (c) a benzonaphthyridine compound, wherein the inclusion of the polymeric particles in the composition elicits an enhanced immune response when administered to a vertebrate subject.
An immunogenic composition comprising (a) a first antigen, (b) polymeric particles that comprise a polymer that comprises a biodegradable polymer block and a hydrophilic polymer block, and (c) a benzonaphthyridine compound, wherein the inclusion of the polymeric particles in the composition elicits an enhanced immune response when administered to a vertebrate subject.
Dependencies are inferred from the claim text.