Treatment of pigs with PCV2 antigen

A method for the treatment of a PCV2 infection or for the reduction of the severity of clinical symptoms caused by PCV2 infection in piglets, wherein the piglets have anti-PCV2 antibodies with an anti-PCV2 antibody titer of more than 1:1000 as determined in a PCV-specific indirect immunofluorescence assay, comprising administering a single efficacious dose of a vaccine composition comprising a PCV2 ORF2 antigen to a piglet wherein the treatment of PCV2 infection or the reduction of the severity of clinical symptoms caused by or associated with a PCV2 infection occurs after the single efficacious dose of the vaccine composition comprising PCV2 ORF2 antigen.

A method for the treatment of PCV2 infection in a piglet or for the reduction of the severity of clinical symptoms caused by or associated with a PCV2 infection in a piglet, wherein the piglet has anti-PCV2 antibodies, the method comprising the step of:

• administering a single efficacious dose of an immunogenic composition comprising PCV2 ORF2 protein to a piglet, wherein the PCV2 ORF2 protein has at least 90% sequence homology with SEQ ID NO. 11 and wherein the treatment of PCV2 infection or the reduction of the severity of clinical symptoms caused by or associated with a PCV2 infection occurs after the single efficacious dose of said immunogenic composition comprising PCV2 ORF2 protein.