Methods and materials for treating cancer
AssigneesMayo Foundation for Medical Education and Research, University of Leeds
InventorsJose S. Pulido, Richard G. Vile, Timothy J. Kottke, Alan A. Melcher, Peter Selby
Life of this patent
Estimating the term…
Abstract
This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.
Claims13
A method for identifying, from a second nucleic acid library, a nucleic acid encoding an antigen having the ability, in combination with at least two other antigens, to stimulate an anti-cancer response, wherein said second nucleic acid library is a library of virally-expressed nucleic acid members and has the ability to stimulate an anti-cancer response when administered to a mammal having cancer, wherein said method comprises:
- (a) contacting immune cells with an aliquot of said second nucleic acid library to form a collection of virally infected cells, wherein said immune cells were obtained from a mammal that exhibited a reduction in the number of cancer cells following administration of a first nucleic acid library,
- (b) obtaining a cell from said collection of virally infected cells that secretes an IL-17 polypeptide, wherein said cell contains a nucleic acid member of said second nucleic acid library, and
- (c) determining the sequence of said nucleic acid member of said cell, wherein said nucleic acid member is said nucleic acid encoding an antigen having the ability, in combination with at least two other antigens, to stimulate an anti-cancer response.
Dependencies are inferred from the claim text.