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AssigneeYeda Research and Development Co. Ltd.
InventorsMichal Eisenbach-Schwartz, Ester Yoles, Oleg Butovsky, Jonathan Kipnis
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Methods and compositions are provided for treatment of neurodegenerative diseases in which there is accumulation of misfolded and/or aggregated proteins, excluding prion diseases. In particular, the invention relates to treatment of the neurodegenerative diseases Huntington's disease (HD), Alzheimer's disease (AD) or Parkinson's disease (PD), by administration of an agent selected from the group consisting of (i) Copolymer 1, (ii) a Copolymer 1-related peptide, (iii) a Copolymer 1-related polypeptide, and (iv) T cells activated with (i), (ii) or (iii).
A method for treating a neurodegenerative disorder or disease selected from the group consisting of Huntington's disease and Alzheimer's disease, said method comprising administering Copolymer 1 without an adjuvant to an individual in need thereof, wherein said administering is once every 1, 4 or 6 weeks.
A method for reducing disease progression, and/or for protection from neurodegeneration and/or protection from glutamate toxicity in a patient suffering from Alzheimer's disease, which comprises administering an effective amount of Copolymer 1 without an adjuvant to an individual in need thereof, wherein said administering is once every 1, 4 or 6 weeks.
A method for reducing disease progression, and/or for protection from neurodegeneration and/or protection from glutamate toxicity in a patient suffering from Huntington's disease, which comprises administering an effective amount of Copolymer 1 without an adjuvant to said patient in need thereof, wherein said administering is once every 1, 4 or 6 weeks.
A method for treating or preventing neurodegeneration and cognitive decline and dysfunction associated with Huntington's disease or Alzheimer's disease, said method comprising administering Copolymer 1 without an adjuvant to an individual in need, wherein said administering is once every 1, 4 or 6 weeks.
Dependencies are inferred from the claim text.