Therapeutic combinations for use in neoplasia
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsSatya Narayan, Aruna S. Jaiswal, David A. Ostrov, Sukwon Hong
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Abstract
The invention features compositions and methods that are useful for the treatment of neoplasia (e.g., pancreatic cancer, colon cancer, brain cancer) by increasing DNA damage, reducing nucleotide synthesis, and reducing base excision repair (BER).
Claims6
A method for increasing cytotoxicity of a chemotherapeutic agent in a subject, the method comprising administering to the subject NSC-30049 or an analog thereof, an alkylating agent and an agent that binds to ribonucleotide reductase (RR) and reduces nucleotide synthesis relative to a reference;
- wherein the analog is of formula:
- wherein X is F, Cl, Br, or OH;
- and
- NR3 is
A method for increasing cytotoxicity of a chemotherapeutic agent in a subject, the method comprising administering to the subject NSC-30049, cisplatin (CDDP), and gemcitabine (dFdC).
Dependencies are inferred from the claim text.